Publications

  1. Choi A.J., Bennison D.J., Kulkarni E., Sun H., Li H., Bradshaw J., Yeap H.W., Lim, N., Mishra V., Crespo-Puig A., Davies F., Sriskandan S., Shenoy A. R. (2024) Aminoglycoside heteroresistance in Enterobacter cloacae is driven by the cell envelope stress response. mBio, 0:e01699-24. 10.1128/mbio.01699-24

  2. Fisch D., Pfleiderer M.M., Anastasakou E., Mackie G.M., Wendt F., Liu X., Clough B., Lara-Reyna S., Encheva V., Snijders A.P., Bando H., Yamamoto M., Beggs A.D., Mercer J., Shenoy A. R., Wollscheid B., Maslowski K.M., Galej W.P., Frickel E.M. (2023) Science. 382:eadg2253. 10.1126/science.adg2253

  3. Mishra V., Crespo-Puig A., McCarthy C., Masonou T., Glegola-Madejska I., Dejoux A., Dow G., Eldridge M.J.G., Marinelli L.H., Meng M., Wang S., Bennison D.J., Shenoy A. R. (2023) IL-1β turnover by TRIP12 and AREL1 ubiquitin ligases and UBE2L3 limits inflammation. Nat Commun. 14:4385. 10.1038/s41467-023-40054-x

  4. Shenoy A. R. (2021) grafify: an R package for easy graphs, ANOVAs and post-hoc comparisons (Version v1.4.1). Zenodo. 10.5281/zenodo.5136508

  5. Kennedy C. R., Goya Grocin A., Kovačič T., Singh R., Ward J. A., Shenoy A. R.*, Tate E. W.* (2021) A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 16 :982-990. 10.1021/acschembio.1c00218. (* joint correspondence)

  6. Zaveri A., Bose A., Sharma S., Rajendran A., Biswas P., Shenoy A. R., Visweswariah S.S. (2021) Mycobacterial STAND adenylyl cyclases: the HTH domain binds DNA to form biocrystallized nucleoids. Biophys J., 120:1231-1246. 10.1016/j.bpj.2020.11.008

  7. Zhong Q, Roumeliotis T.I., Kozik Z., Cepeda-Molero M., Fernández L.A., Shenoy A. R., Bakal C., Frankel G., Choudhary J.S. (2020). Clustering of Tir during enteropathogenic E. coli infection triggers Ca2+ influx-dependent pyroptosis in intestinal epithelial cells. PLOS Biol, 18:e3000986. 10.1371/journal.pbio.3000986

  8. Mylona E, Sanchez-Garrido J, Hoang Thu TN, Dongol S, Karkey A, Baker S, Shenoy A. R.*, Frankel G*. (2021) Very long O-antigen chains of Salmonella Paratyphi A inhibit inflammasome activation and pyroptotic cell death. Cell Microbiol. 23:e13306. 10.1111/cmi.13306. (* joint correspondence)

  9. Fisch D., Clough B., Domart M-C, Encheva V., Bando H., Snijders A.P., Collinson L.M., Yamamoto M., Shenoy A. R.*, Frickel E.M.* (2020) Human GBP1 differentially targets Salmonella and Toxoplasma to license recognition of microbial ligands and caspase-mediated death. Cell Rep.,32:108008. 10.1016/j.celrep.2020.108008 (* joint correspondence)

  10. Sanchez-Garrido J. & Shenoy A. R. (2020) Regulation and repurposing of nutrient sensing and autophagy in innate immunity. Autophagy10.1080/15548627.2020.1783119

  11. Sanchez-Garrido J., Slater S.L., Clements A., Shenoy A. R., Frankel G. (2020) Vying for the control of inflammasomes: The cytosolic frontier of enteric bacterial pathogen-host interactions. Cell Microbiol. 22:e13184. 10.1111/cmi.13184

  12. Subbarao S., Sanchez-Garrido J., Krishnan N., Shenoy A. R.*, Robertson B.D.* (2020) Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages. Sci Rep. 10:3709. 10.1038/s41598-020-60560-y (* joint correspondence)

  13. Prasad H., Shenoy A. R., Visweswariah S.S. (2020) Cyclic nucleotides, gut physiology and inflammation. FEBS J. 287:1970-1981. 10.1111/febs.15198

  14. Watson J.L., Sanchez-Garrido J., Goddard P.J., Torraca V., Mostowy S., Shenoy A. R., Clements A. (2019) Shigella sonnei O-Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation. mBio. 10:e02654-19. 10.1128/mBio.02654-19

  15. Mullineaux-Sanders C., Sanchez-Garrido J., Hopkins E.G.D., Shenoy A. R., Barry R., Frankel G. (2019) Citrobacter rodentium-host-microbiota interactions: immunity, bioenergetics and metabolism. Nat Rev Microbiol. 17:701-715. 10.1038/s41579-019-0252-z

  16. Fisch D., Bando H., Clough B., Hornung V., Yamamoto M., Shenoy A. R.*, Frickel E.M.* (2019) Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 38: e100926. 10.15252/embj.2018100926 (* joint correspondence)

  17. Ahmad A., Mashbat B., Leung C., Brookes C., Hamad S., Krokowski C., Shenoy A. R., Lorenzo L., Levin M., O’Hare P., Zhang, S-Y., Casanova, J-L., Mostowy S., Sancho-Shimizu V. (2019) Human TBK1 is required for early autophagy induction upon HSV1 infection. J Allergy Clin Immunol. S0091-6749, 31364-2. 10.1016/j.jaci.2018.09.013

  18. Sanchez-Garrido, S, Sancho-Shimizu, V and Shenoy A. R. (2018) Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient-sensing. Sci Signal. 11, pii: eaat6903. 10.1126/scisignal.aat6903

  19. Goddard P.J., Sanchez-Garrido J., Slater S.L., Kalyan M., Ruano-Gallego D., Marchès O., Fernández L.Á., Frankel G., Shenoy A. R. Enteropathogenic Escherichia coli stimulates effector-driven rapid caspase-4 activation in human macrophages. (2019) Cell Rep. 27, 1008-1017. 10.1016/j.celrep.2019.03.100

  20. Shenoy A. R., Furniss R.C.D., Goddard P.J., Clements A. Modulation of host cell processes by T3SS effectors. (2018). Curr Top Microbiol Immunol. 416, 73-115. 10.1007/82_2018_106

  21. Bist P., Cheong W.S., Ng A., Dikshit N., Kim, B-H, Pulloor N., Khameneh H.J., Hedl M., Shenoy A. R., Balamuralidhar. V., Malik M., Hong M., Neutzner A., Chin K-C, Kobayashi K., Bertoletti A., Mortellaro A., Abraham A., MacMicking J.D., Xavier R., and Sukumaran B. (2017) E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP. Nat Commun. 8, 15865. 10.1038/ncomms15865

  22. Mazon-Moya M.J., Willis A.R., Torraca V., Boucontet L., Shenoy A. R., Colucci-Guyon E., Mostowy S. (2017) Septins restrict inflammation and protect zebrafish larvae from Shigella infection. PLoS Pathog. 13(6):e1006467. 10.1371/journal.ppat.1006467

  23. Eldridge M.J.G., Sanchez-Garrido J., Hoben G.F., Goddard P.J., Shenoy A. R. (2017) The atypical ubiquitin E2 conjugase UBE2L3 is a caspase-1 target and controls IL-1beta secretion by inflammasomes. Cell Reports. 18, 1285-1297. 10.1016/j.celrep.2017.01.015

  24. Pallett M.A., Crepin V.F., Serafini N., Habibzay M., Kotik O., Sanchez-Garrido, J, Di Santo J.D., Shenoy A. R., Berger C.N., Frankel G. (2017) Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 10, 602-612. 10.1038/mi.2016.77

  25. Thurston T.L.M., Matthews S.A., Jennings E., Alix E. Shao F., Shenoy A. R., Birrell M.A., Holden D.W. (2016) Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 7,13292.  10.1038/ncomms13292

  26. Surana S., Shenoy A. R.* & Krishnan Y.* (2015) Designing DNA nanodevices for compatibility with the immune system of higher organisms. Nat Nanotechnol. 10, 741-747. 10.1038/nnano.2015.180 (* joint correspondence)

  27. Mostowy, S*. & Shenoy A. R.* (2015) The cytoskeleton in cell-autonomous immunity: structural determinants of host defence. Nat Rev Immunol. 15, 559-573 10.1038/nri3877 (* joint correspondence)

  28. Eldridge M.J.G. & Shenoy A. R. (2015) Antimicrobial Inflammasomes: Unified Signalling Themes that Detect Diverse Bacterial Pathogens. Curr Opin Microbiol. 23, 32-4. 10.1016/j.mib.2014.10.008

  29. Kim B. H., Shenoy A. R., Kumar P., Bradfield C. J. & MacMicking J. D. (2012) IFN-inducible GTPases in host cell defense. Cell Host Microbe. 12, 432-444. 10.1016/j.chom.2012.09.007

  30. Matsuzawa T., Kim B. H., Shenoy A. R., Kamitani S., Miyake M. & Macmicking J. D. (2012) IFN-γ Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway. J Immunol. 189, 813-818. 10.4049/jimmunol.1102041

  31. Shenoy A. R., Wellington D. A., Kumar P., Kassa H., Booth C. J., Cresswell P. & MacMicking J. D. (2012) GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science. 336, 481-485. 10.1126/science.1217141

  32. Kim B. H., Shenoy A. R., Kumar P., Das R., Tiwari S. & MacMicking J. D. (2011) A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science. 332, 717-721. 10.1126/science.1201711

  33. Biswas K. H., Shenoy A. R., Dutta A. & Visweswariah S. S. (2009) The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. J Mol Evol. 68, 587-602. 10.1007/s00239-009-9242-5

  34. Tyagi R., Shenoy A. R. & Visweswariah S. S. (2009) Characterization of an evolutionarily conserved metallophosphoesterase that is expressed in the fetal brain and associated with the WAGR syndrome. J Biol Chem. 284, 5217-28. 10.1074/jbc.M805996200

  35. Dass B. K., Sharma R., Shenoy A. R., Mattoo R. & Visweswariah S. S. (2008) Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis. J Bacteriol. 190, 3824-34. 10.1128/JB.00138-08

  36. Shenoy A. R., Kim B. H., Choi H. P., Matsuzawa T., Tiwari S. & MacMicking J. D. (2007) Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families. Immunobiology. 212, 771-84. 10.1016/j.imbio.2007.09.018

  37. Shenoy A. R., Capuder M., Draskovic P., Lamba D., Visweswariah S. S. & Podobnik M. (2007) Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. J Mol Biol. 365, 211-25. 10.1016/j.jmb.2006.10.005

  38. Shenoy A. R.* & Visweswariah S. S.* (2006) Mycobacterial adenylyl cyclases: biochemical diversity and structural plasticity. FEBS Lett. 580, 3344-52. 10.1016/j.febslet.2006.05.034 (* joint correspondence)

  39. Shenoy A. R. & Visweswariah S. S. (2006) New messages from old messengers: cAMP and mycobacteria. Trends Microbiol. 14, 543-50. 10.1016/j.tim.2006.10.005

  40. Macario A. J., Brocchieri L., Shenoy A. R. & de Macario E. C. (2006) Evolution of a Protein-Folding Machine: Genomic and Evolutionary Analyses Reveal Three Lineages of the Archaeal hsp70(dnaK) Gene. J Mol Evol. 63, 74-86. 10.1007/s00239-005-6207-1

  41. Jaleel M., Saha S., Shenoy A. R. & Visweswariah S. S. (2006). The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site. Biochemistry. 45, 1888-1898. 10.1021/bi052089x

  42. Ketkar A. D., Shenoy A. R., Ramagopal A. U., Visweswariah S. S. & Suguna K. (2006). A structural basis for the role of the nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis. J Mol Biol. 356, 904-916. 10.1016/j.jmb.2005.12.017

  43. Shenoy A. R., Sreenath N. P., Podobnik M., Kovacevic M. & Visweswariah S. S. (2005). The Rv0805 gene from Mycobacterium tuberculosis encodes a 3’, 5’-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. Biochemistry. 44, 15695-15704. 10.1021/bi0512391

  44. Shenoy A. R., Srinivas A., Mahalingam M. & Visweswariah S. S. (2005). An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium. Biochimie. 87, 557-563. 10.1016/j.biochi.2005.01.017

  45. Shenoy A. R., Sreenath N. P., Mahalingam M. & Visweswariah S. S. (2005). Characterization of phylogenetically distant members of the adenylyl cyclase family from mycobacteria: Rv1647 from M. tuberculosis and its ortholog ML1399 from M. leprae. Biochem J. 387, 541-551. 10.1042/BJ20041040

  46. Shenoy A. R. & Visweswariah S. S. (2004). Class III nucleotide cyclases in bacteria: conservation and divergence of enzymes in Mycobacterium tuberculosis. Tuberculosis Current Research Trends (Sharma D. P., Ed.)

  47. Shenoy A. R. * & Visweswariah S. S.* (2004). Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases. FEBS Lett. 561, 11-21. 10.1016/s0014-5793(04)00128-0 (* joint correspondence)

  48. Jaleel M., Shenoy A. R. & Visweswariah S. S. (2004). Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. Biochemistry. 43, 8247-55. 10.1021/bi036234n

  49. Ketkar A. D., Shenoy A. R., Kesavulu M. M., Visweswariah S. S. & Suguna K. (2004). Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 60, 371-373. 10.1107/S0907444903028002

  50. Shenoy A. R.*, Sivakumar K., Krupa A., Srinivasan N. & Visweswariah S. S.* (2004). A survey of nucleotide cyclases in Actinobacteria: unique domain organization and expansion of the class III cyclase family in Mycobacterium tuberculosis. Comp Funct Genomics. 5, 17-38. 10.1002/cfg.349 (* joint correspondence)

  51. Shenoy A. R., Srinivasan N., Subramaniam M. & Visweswariah S. S. (2003). Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization. FEBS Lett. 545, 253-259. 10.1016/s0014-5793(03)00580-5

  52. Shenoy A. R. & Visweswariah S. S. (2003). Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA. Anal Biochem. 319, 335-6. 10.1016/s0003-2697(03)00286-0

  53. Shenoy A. R., Srinivasan N. & Visweswariah S. S. (2002). The ascent of nucleotide cyclases: conservation and evolution of a theme. J Biosci. 27, 85-91. 10.1007/BF02703763

  54. Shenoy A. R. (2000). His kinase or mine? Histidine kinases through evolution. J Biosci. 25, 317-22. 10.1007/BF02703784